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Capsule of brown fat cells reduces abdominal fat in mice trials

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We’ve seen a number of encouraging developments in recent times related to research into turning calorie-storing white fat cells into heat-generating brown fat cells as a potential weapon in the fight against obesity and related diseases, such as diabetes. The latest news comes out of Ohio State University where researchers have reduced the amount of belly fat in mice by 20 percent by injecting a tiny capsule containing brown fat cells into their abdomens.

The capsules used in the study contained brown fat thermogenic cells, which burn fat to generate heat, that were combined with genetically modified cells that were missing an enzyme that leads to the growth of abdominal, or visceral, fat. Abdominal fat surrounds the internal organs and is linked to a higher risk of type 2 diabetes, cancer and heart disease. These cells were placed inside a capsule that allowed for the release of its contents without triggering an immune response.

When the capsules were injected into the abdomens of the mice subjects, the researchers found that the injected cells acted like “missionaries” that converted existing abdominal white fat cells into heat-generating brown fat cells. This resulted in an initial dramatic 10 percent weight loss…

Importantly, the amount of subcutaneous fat, which is found just beneath the skin and aids in regulating the body’s temperature by forming an insulating layer, remained unchanged…

Although studies in larger animals will be needed before human trials could begin, Ziouzenkova said any future therapy based on the research would be best suited to patients who develop abdominal fat with aging and aren’t able to exercise and shouldn’t dramatically reduce their calorie intake as it could result in a reduction of beneficial subcutaneous fat.

This is worth tracking as they get up into human studies and trials. I have beaucoup peers among the grayheads of the world who could use an aid like this. It seems to be a low risk procedure.

We’ll probably get to watch lots of Hollywood beauty queens do their own trials before it’s approved by the FDA.

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Written by Ed Campbell

September 6, 2012 at 10:00 pm

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