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Posts Tagged ‘mutations

E-cigarettes change cells similar to those affected by tobacco

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Electronic cigarettes can change gene expression in a similar way to tobacco, according to one of the first studies to investigate the biological effects of the devices.

Presented at the American Association for Cancer Research annual meeting on 6 April in San Diego, California, the research looked at human bronchial cells that contained some mutations found in smokers at risk of lung cancer. The cells were immortalized, grown in culture medium that had been exposed to e-cigarette vapour and their gene expression profiled.

The researchers found that the cells grown in medium exposed to the vapour of e-cigarettes showed a similar pattern of gene expression to those grown in a medium exposed to tobacco smoke…

The changes are not identical, says study researcher Avrum Spira, who works on genomics and lung cancer at Boston University in Massachusetts. But “there are some striking similarities”, he says. The team is now evaluating whether the alterations mean that cells behave more like cancer cells in culture.

I don’t doubt the companies making a buck from this latest tobacco “substitute” will fight to the death to protect their profits. Your death. Their profits.

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Written by Ed Campbell

April 11, 2014 at 2:00 am

We all have hundreds of DNA flaws waiting to do us in! Or not.

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The price of silent mutations

Everyone has on average 400 flaws in their DNA, a UK study suggests…Most are “silent” mutations and do not affect health, although they can cause problems when passed to future generations…Others are linked to conditions such as cancer or heart disease, which appear in later life, say geneticists.

The evidence comes from the 1,000 Genomes project, which is mapping normal human genetic differences, from tiny changes in DNA to major mutations.

In the study, 1,000 seemingly healthy people from Europe, the Americas and East Asia had their entire genetic sequences decoded, to look at what makes people different from each other, and to help in the search for genetic links to diseases.

The new research, published in The American Journal of Human Genetics, compared the genomes of 179 participants, who were healthy at the time their DNA was sampled, with a database of human mutations developed at Cardiff University.

It revealed that a normal healthy person has on average about 400 potentially damaging DNA variations, and two DNA changes known to be associated with disease.

“Ordinary people carry disease-causing mutations without them having any obvious effect,” said Dr Chris Tyler-Smith, a lead researcher on the study from the Wellcome Trust Sanger Institute, Cambridge.

He added: “In a population there will be variants that have consequences for their own health.”

The research gives an insight into the “flaws that make us all different, sometimes with different expertise and different abilities, but also different predispositions in diseases,” said Prof David Cooper of Cardiff University, the other lead researcher of the study.

“Not all human genomes have perfect sequences,” he added. “The human genome is packed with pervasive, architectural flaws.”

It has been known for decades that all people carry some genetic mutations that appear to cause little or no harm. Many are only damaging if they are passed on to children who inherit another copy of the faulty gene from the other parent.

In others – around one in ten of those studied – the mutation causes only a mild condition, appears to be inactive, or does not manifest itself until later life.

Databases of human mutations, like the one at Cardiff University, will have increasing importance in the future, as we move into the era of personalised medicine…But as DNA sequencing becomes more widespread, ethical dilemmas will arise about what to tell people about their genes, especially when many risks are uncertain.

We all understand the range of dead ends available for time-wasting by ethicists. Especially those with one or another superstition to justify. I come down – in advance – on the side of the simplest and most democratic premise: knowledge is always useful. I don’t care if someone decides if it’s scary or silly – I have the right to know.

Feel like eating trout – downstream from mining operations?

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Photographs of variously mutated brown trout were relegated to an appendix of a scientific study commissioned by the J. R. Simplot Company, whose mining operations have polluted nearby creeks in southern Idaho. The trout were the offspring of local fish caught in the wild that had been spawned in the laboratory. Some had two heads; others had facial, fin and egg deformities.

Yet the company’s report concluded that it would be safe to allow selenium — a metal byproduct of mining that is toxic to fish and birds — to remain in area creeks at higher levels than are now permitted under regulatory guidelines. The company is seeking a judgment to that effect from the Environmental Protection Agency. After receiving a draft report that ran hundreds of pages, an E.P.A. review described the research as “comprehensive” and seemed open to its findings, which supported the selenium variance for Simplot’s Smoky Canyon mine.

But when other federal scientists and some environmentalists learned of the two-headed brown trout, they raised a ruckus, which resulted in further scientific review that found the company’s research wanting.

Now, several federal agencies, an array of environmental groups and one of the nation’s largest private companies are at odds over selenium contamination from the Idaho phosphate mine, the integrity of the company’s research, and what its effect will be on future regulatory policy.

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Written by Ed Campbell

February 24, 2012 at 10:00 pm

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