Insulin directly linked to core body temperature

A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin — a hormone long associated with metabolism and metabolic disorders such as diabetes — and core body temperature. While much research has been conducted on insulin since its discovery in the 1920s, this is the first time the hormone has been connected to the fundamental process of temperature regulation…

The scientists found that when insulin was injected directly into a specific area of the brain in rodents, core body temperature rose, metabolism increased, and brown adipose (fat) tissue was activated to release heat. The research team also found that these effects were dose-dependent — up to a point, the more insulin, the more these metabolic measures rose.

“Scientists have known for many years that insulin is involved in glucose regulation in tissues outside the brain,” said neurobiologist Manuel Sanchez-Alavez… “The connection to temperature regulation in the brain is new.”

In addition to suggesting a fresh perspective on diseases such as diabetes that involve the disruption of insulin pathways, the study adds to our understanding of core body temperature — the temperature of those parts of the body containing vital organs, namely the trunk and the head. Normally, core body temperature stays within a narrow range so that key enzymatic reactions can occur. When core body temperature goes outside this range for prolonged periods — higher as in fever, or lower as in hypothermia — the result is harm to the body…

“Our paper highlights the possibility that differences in core temperature may play a role in obesity and may represent a therapeutic area in future drug design,” added Olivia Osborn.

Bravo!

4 thoughts on “Insulin directly linked to core body temperature

  1. Mr. Fusion says:

    Dieters also seem to be always cold. I attributed this to their having to burn stored fat instead of carbs. Maybe this process too is dependent upon insulin.

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