Know-Nothing Congress roadblocks US policy on mitochondrial therapy

Scientists believe they can now remove disease-causing mitochondrial DNA from human embryos, providing new cures for previously untreatable conditions, but the policy signals coming from Washington DC are in stark contradiction, according to a new Viewpoint essay published in JAMA.

On Feb. 3, 2016, the Health and Medicine Division of the National Academies issued a report on mitochondrial replacement therapy commissioned by the Food and Drug Administration. The division recommended that under certain conditions, MRT clinical trials should be allowed to proceed. But just six weeks before, President Obama signed an appropriations bill that included a bit of language essentially forbidding those trials…

❝ “One big step forward was taken by the IOM report when it concluded that it is “ethically permissible” to embark on first-in-human clinical trials of MRT subject to rigorous safety and efficacy imperatives,” wrote Dr. Eli Adashi…and I. Glenn Cohen…“However, two steps back were taken with the enactment of a policy rider which precludes the FDA from further consideration of MRT…”

Meanwhile in the United Kingdom, the government has approved MRT clinical trials and some might begin this year. But despite the National Academies recommending a similar advance to the FDA, legislation has left U.S. policy at a standstill, wrote Adashi and Cohen.

Whether or not the eventual births of disease-free children in the UK will change congressional hearts and minds remains to be seen,” they wrote. “Failing such, progress in the prevention of mitochondrial DNA diseases will remain the domain of a biomedical enterprise an ocean away.”

The same ignoranus mindset George W Bush brought to US government is alive and well in a Congress governed by shortsighted and foolish conservatives, embraced by Republicans, Tea Party Trumpkins and Blue Dog Democrats. American voters may never learn to vote in their own economic and social interest; but, you’d think they’d eventually figure out that passing laws that help your children to die really ain’t too bright.

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