Some Antibiotics in First Trimester Raise Risk of Major Birth Defects

❝ Several common types of antibiotics were linked both to major congenital and to organ specific malformations in infants when taken during the first trimester of pregnancy, a retrospective Canadian cohort study found.

❝ Exposure to antibiotics, such as clindamycin, doxycycline, quinolones, macrolides and phenoxymethylpenicillin, increased the risk of these birth defects, reported Flory T. Muanda, MD, of the University of Montreal, and colleagues.

However, there was no increased risk of major congenital malformations linked to exposure to amoxicillin, cephalosporins, or nitrofurantoin, the authors wrote in the British Journal of Clinical Pharmacology…

❝ Researchers examined data from the Quebec pregnancy cohort, an ongoing population-based cohort with data on all pregnancies covered by Quebec Public Prescription Drug Insurance from 1998 to 2008, comprising about 140,000 infants.

Be aware.

❝ They concluded that, despite the small absolute risks associated with these birth defects, “physicians should consider prescribing safer antibiotics for the treatment of maternal infections when possible.”

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