‘Liquid biopsy’ blood test predicts cancer

A new blood test that can detect methylation of DNA can accurately predict whether a person has any one of 50 cancers and where the tumour is growing…

…In all, more than 15,000 volunteers from over 140 clinics in North America took part, and their samples revealed that this ‘liquid biopsy’ had a 0.7% false positive rate for cancer detection. The test was also able to predict the tissue that the cancer originated in with more than 90% accuracy. It performed best on 12 of the most common cancers, including ones that are most lethal and have no established screening paradigms such as pancreatic and ovarian cancers…

The test works because when a tumour cell dies its DNA enters the bloodstream. This genetic material still carries methylation patterns that differ from healthy cells, and this is what the liquid biopsy measures. ‘The test exploits the fact that cancers are abnormally methylated, and … that different cancers have different methylation patterns,’ explains study co-author Eric Klein from the Cleveland Clinic in Ohio.

Fortunately, solid scientific research finds a way to keep to task, direction mostly unaffected by the politics of ignorance.

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