36 thoughts on “Rest easy, my child…

  1. Update says:

    AstraZeneca shares turn negative after Brazilian health authority says volunteer in Covid vaccine study dies https://www.cnbc.com/2020/10/21/astrazeneca-shares-slide-after-brazilian-health-authority-says-volunteer-in-covid-vaccine-study-dies.html
    The news comes as the Food and Drug Administration still has a late-stage clinical trial from AstraZeneca on hold in the United States. That means the company is unable to administer second doses of its two-dose vaccine regimen to U.S. participants. https://www.reuters.com/article/health-coronavirus-astrazeneca-usa-exclu/exclusive-u-s-trial-of-astrazeneca-covid-19-vaccine-may-resume-this-week-sources-idUSKBN2752C3

  2. Poco a poco says:

    “Anika Chebrolu, 14, was named the winner of the 2020 3M Young Scientist Challenge, a competition for middle school scientists. The eighth-grader’s project won her a $25,000 cash prize.
    “I isolated a lead compound from a database of almost 698 million molecules,” said Chebrolu.
    That discovery, which she hopes will lead to a new weapon against COVID-19, began two years ago while Chebrolu was researching the Spanish flu pandemic.” (CBS News) https://www.cbsnews.com/news/covid-cure-14-year-old-girl-wins-25k-prize-for-research/

    “14-Year-Old Researches Spike Protein of SARS-CoV-2 Virus to Develop Novel Antiviral Drug to Combat Spread of COVID-19” (3M press release) https://news.3m.com/English/press-releases/press-releases-details/2020/Americas-Top-Young-Scientist-of-2020-14-Year-Old-Researches-Spike-Protein-of-SARS-CoV-2-Virus-to-Develop-Novel-Antiviral-Drug-to-Combat-Spread-of-COVID-19/default.aspx “Anika used in-silico methodology for drug discovery to find a molecule that can selectively bind to the spike protein of the SARS-CoV-2 virus to find a cure for COVID-19.” This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201014005340/en/

  3. Nightmare says:

    “Infuriated by the FDA’s defiance in a showdown over the Trump administration’s standards for authorizing a coronavirus vaccine, health secretary Alex Azar has spent recent weeks openly plotting the ouster of FDA chief Stephen Hahn.
    Azar has vented to allies within the Health and Human Services Department about his unhappiness with the top official in charge of the vaccine process, and discussed the prospect of seeking White House permission to remove him, a half-dozen current and former administration officials said.” https://www.politico.com/news/2020/10/22/azar-plans-oust-hahn-fda-431139
    “HHS Secretary Alex Azar Says Coronavius Vaccines “Could Be” Available By Year’s End” https://www.ktts.com/2020/10/22/hhs-secretary-alex-azar-says-coronavius-vaccines-could-be-available-by-years-end/
    “Coronavirus Roundup: Critical FDA Meeting Today; Fauci On Mistrust of Government (Oct 22, 2020) https://www.govexec.com/workforce/2020/10/coronavirus-roundup-critical-fda-meeting-today-fauci-spoke-about-mistrust-government/169464/

  4. Heads up says:

    Pfizer and German biotechnology firm BioNTech announced Monday that its front-runner coronavirus vaccine was more than 90 percent effective at protecting people, compared with a placebo. Health reporter Carolyn Y. Johnson writes that it’s the “strongest signal yet” that the vaccine race could succeed, and break scientific speed records in the process. https://www.washingtonpost.com/health/2020/11/09/pfizer-coronavirus-vaccine-effective/
    “The results are really quite good, I mean extraordinary,” Anthony S. Fauci told The Post after speaking with Pfizer’s chief executive. Other health experts said the announcement was positive news, but that hurdles still remain. Crucial details need to be examined, like evaluating the vaccine’s long-term safety and efficacy. Pfizer said it plans to submit for FDA emergency authorization later this month.
    The promising development came as the United States surpassed 10 million coronavirus cases, just 10 days after hitting 9 million. The average number of daily new infections has exceeded 100,000, and public health experts continue to warn the country is entering the pandemic’s worst phase yet. https://www.washingtonpost.com/national/record-breaking-wave-of-coronavirus-cases-continues-to-sweep-the-nation/2020/11/08/4d2821e4-21ee-11eb-a688-5298ad5d580a_story.html

  5. Update says:

    (11/13/20) “Scientist behind Pfizer’s COVID-19 vaccine makes bold claim: It can stop pandemic” https://nypost.com/2020/11/13/man-behind-covid-19-vaccine-says-it-will-bash-the-virus-over-head/
    (11/10/20): “Most States Aren’t Ready to Distribute the Leading COVID-19 Vaccine : A review of state distribution plans reveals that officials don’t know how they’ll deal with the difficult storage and transport requirements of Pfizer’s vaccine, especially in the rural areas currently seeing a spike in infections. https://www.propublica.org/article/most-states-arent-ready-to-distribute-the-leading-covid-19-vaccine
    (Oct 30, 2020): “States say they lack federal funds to distribute coronavirus vaccine as CDC tells them to be ready by Nov. 15
    “It’s kind of like setting up tent poles without having the tent,” one state health officer said” https://www.washingtonpost.com/health/2020/10/29/covid-vaccine-states-need-money/
    (11/13/20): “President Trump threatens to withhold COVID-19 vaccine from New York in new feud with Governor Cuomo” https://www.businessinsider.com/trump-threatens-to-withhold-vaccine-new-york-feuds-with-cuomo-2020-11

  6. Hope says:

    The most significant coronavirus mutation so far has been detailed in many studies, most of them saying that the D614G mutation has made the virus more infectious. https://bgr.com/2020/09/25/coronavirus-mutation-d614g-houston-study/
    A new paper details an experiment that proves the D614G strain can bind to cells more efficiently, and it also replicates faster than the original strain. https://bgr.com/2020/11/14/coronavirus-vaccine-efficacy-increased-d614g-mutation/
    The researchers believe that since the mutation binds better to cells, it may also help make coronavirus vaccines even more effective. https://science.sciencemag.org/content/early/2020/11/11/science.abe8499

  7. Science be damned says:

    “Moderna says preliminary phase three trial data shows its coronavirus vaccine is more than 94% effective in preventing Covid-19” https://www.cnbc.com/2020/11/16/moderna-says-its-coronavirus-vaccine-is-more-than-94percent-effective.html
    ‘Shares of the company jumped more than 12% in premarket trading.
    Investors were expecting Moderna’s vaccine to be highly effective after Pfizer, another front-runner in the Covid-19 vaccine race, said last week that its product was more than 90% effective. Moderna’s candidate, like that of the Pfizer-BioNTech partnership, is using messenger RNA, or mRNA, technology. It’s a new approach to vaccines that uses genetic material to provoke an immune response.
    Moderna said Monday its vaccine remains stable at 36 to 46 degrees Fahrenheit, the temperature of a standard home or medical refrigerator, for up to 30 days. It can be stored for up to six months at negative 4 degrees Fahrenheit. By comparison, Pfizer’s vaccine requires a storage temperature of minus 94 degrees Fahrenheit.”
    The U.S. had already invested $955 million in Moderna’s Covid-19 vaccine development, bringing its total investment up to $2.48 billion, the company said at the time (August 11, 2020)”
    See https://www.cnbc.com/2020/08/11/trump-says-us-has-reached-deal-with-moderna-for-100-million-doses-of-coronavirus-vaccine.html

  8. p/s says:

    Sinovac Biotech’s experimental COVID-19 vaccine CoronaVac triggered a quick immune response but the level of antibodies produced was lower than in people who had recovered from the disease, preliminary trial results showed on Wednesday.
    CoronaVac and four other experimental vaccines developed in China are currently undergoing late-stage trials to determine their effectiveness in preventing COVID-19.

    How long might immunity to the coronavirus last? Years, maybe even decades, according to a new study — the most hopeful answer yet to a question that has shadowed plans for widespread vaccination.
    Eight months after infection, most people who have recovered still have enough immune cells to fend off the virus and prevent illness, the new data shows. A slow rate of decline in the short term suggests, happily, that these cells may persist in the body for a very, very long time to come. https://www.seattletimes.com/nation-world/immunity-to-the-coronavirus-may-last-years-new-research-suggests/

  9. Doc says:

    AstraZeneca and Oxford University’s potential COVID-19 vaccine produced a strong immune response in older adults, data published on Thursday showed, with researchers expecting to release late-stage trial results by Christmas.
    The data, reported in part last month but published in full in The Lancet medical journal on Thursday, suggest that those aged over 70, who are at higher risk of serious illness and death from COVID-19, could build robust immunity. https://www.aol.com/astrazeneca-covid-19-shot-candidate-071149109-132252851.html
    Johnson & Johnson’s chief scientist said the drugmaker is recruiting over 1,000 people per day for the late-stage trial of its experimental COVID-19 vaccine and expects to have all the data needed to seek U.S. authorization by February or earlier. The vaccine is a single-dose jab as opposed to Moderna and Pfizer’s two-dose candidates https://www.reuters.com/article/us-health-coronavirus-johnson-johnson/jj-expects-data-for-u-s-authorization-of-covid-19-vaccine-by-february-says-head-scientist-idUSKBN27X2R7
    The U.S. Food and Drug Administration said on Tuesday it would make public reviews of all data and information regarding the emergency use authorization granted to COVID-19 drugs and vaccines. https://www.ksl.com/article/50050601/fda-to-make-emergency-use-authorization-data-public-for-covid-19-vaccines
    (Nov 18, 2020): A report released yesterday by the US Government Accountability Office (GAO) says supply chain issues could interfere with a smooth rollout of a COVID-19 vaccine and that the Food and Drug Administration (FDA) should disclose scientific review of vaccine and drug efficacy and safety data when issuing emergency use authorizations (EUAs). https://www.cidrap.umn.edu/news-perspective/2020/11/gao-highlights-covid-vaccine-supply-chain-drug-transparency-issues
    “COVID-19: Federal Efforts Accelerate Vaccine and Therapeutic Development, but More Transparency Needed on Emergency Use Authorizations” GAO-21-207: Published: Nov 17, 2020. https://www.gao.gov/products/GAO-21-207

  10. On your marks... says:
  11. doc says:

    The CDC must be transparent about the side effects people may experience after getting their first shot of a coronavirus vaccine, doctors urged during a meeting Monday with CDC advisors. https://www.cnbc.com/2020/11/23/covid-vaccine-cdc-should-warn-people-the-side-effects-from-shots-wont-be-walk-in-the-park-.html
    “Pfizer and Moderna use mRNA in their COVID-19 vaccines. This never-before-used technology could transform how science fights diseases.” (11/23/20) https://www.usatoday.com/story/news/health/2020/11/23/success-pfizer-moderna-mrna-covid-19-vaccines-ushers-new-era/6311228002/

  12. Geezer says:

    CDC advisory panel’s lone dissenter on why long-term care residents shouldn’t receive Covid-19 vaccine first https://www.statnews.com/2020/12/03/cdc-advisory-panels-lone-dissenter-on-why-long-term-care-residents-shouldnt-receive-covid-19-vaccine-first/
    Helen Keipp Talbot — who is known by her middle name — raised serious concerns during the meeting of the Advisory Committee on Immunization Practices about using the vaccines in the frail elderly, noting there are no data yet to suggest the vaccines work in this population.
    All the U.S.-based Phase 3 trials of Covid vaccines have to include people 65 and older. But none has specifically tested the vaccines in people who are in long-term care. One can’t assume findings in people over age 65 who are healthy enough to be accepted for a clinical trial are indicative of everyone in that demographic, she said.
    At an earlier ACIP meeting, Talbot warned that vaccinating this population at the start of the vaccine rollout is risky, because long-term care residents have a high rate of medical events that could be confused as side effects of vaccination and undermine confidence in the vaccines. “And I think you’re going to have a very striking backlash of, ‘My grandmother got the vaccine and she passed away,’” she said at the time.

    • Mike says:

      “I can no longer sit back and allow communist infiltration, communist indoctrination, communist subversion, and the international communist conspiracy to sap and impurify all our precious bodily fluids!” General Jack Ripper (“Dr. Strangelove or: How I Learned To Stop Worrying and Love the Bomb” 1964)

  13. p/s says:

    “COVID vaccines focus on the spike protein – but here’s another target” https://theconversation.com/covid-vaccines-focus-on-the-spike-protein-but-heres-another-target-150315
    “The Race to Make Vials for Coronavirus Vaccines : A Corning factory in upstate New York is running around the clock to help meet the urgent demand.” (The New Yorker, Dec 7, 2020 issue) https://www.newyorker.com/magazine/2020/12/07/the-race-to-make-vials-for-coronavirus-vaccines photographs, taken by Christopher Payne at two Corning facilities in upstate New York, tell the story of an alternative to borosilicate, called Valor Glass, and its use in the effort to deliver COVID-19 vaccines.

  14. SNAFU says:

    Hospitals around the country have been thrown into confusion after the Trump administration informed state after state that they’ll be getting 25%-40% fewer COVID vaccine doses next week than they’d been expecting – without any further explanation.
    Reportedly a senior administration official said the states had been relying on planning numbers that were reduced because Pfizer committed to supplying fewer doses than originally forecast. https://www.axios.com/pfizer-vaccine-shortage-governors-064228c7-1cd1-4a07-86a1-03211a6c8e40.html
    See also “Supply issues hampering Pfizer providing additional vaccine faster” (12/16/20) https://www.cnn.com/2020/12/16/politics/coronavirus-vaccine-pfizer-supply-issues/index.html
    (12/17/20): Pfizer said in a statement that it is “not having any production issues.” Also “[N]o shipments containing the vaccine are on hold or delayed. This week, we successfully shipped all 2.9 million doses that we were asked to ship by the U.S. Government to the locations specified by them.”
    “We have millions more doses sitting in our warehouse but, as of now, we have not received any shipment instructions for additional doses.” https://pfe-pfizercom-d8-prod.s3.amazonaws.com/2020-12/COVID%2019%20Vaccine%20Production%20Distribution%20Statement%20121720.pdf?qkSfPpeyLDVmlkO6VoFoGslJEB7HB8YO

  15. Fake news says:

    In the coming months, U.S. Immigration and Customs Enforcement (ICE) Homeland Security Investigations (HSI) anticipates that high public demand for access to vaccines and treatments will lead to illegal attempts to introduce counterfeit versions of these items into U.S. and global marketplaces. In response, HSI has initiated Operation Stolen Promise 2.0, which expands the focus of OSP to address this emerging public health threat. https://www.ice.gov/topics/operation-stolen-promise

    • Anti-Vaxxer? says:

      The Wisconsin pharmacist accused of intentionally sabotaging more than 500 doses of the coronavirus vaccine at Christmas time told police he did it because he believed the drug is somehow hazardous. https://www.npr.org/2021/01/04/953348619/pharmacist-who-spoiled-more-than-500-vaccine-doses-said-he-thought-they-were-uns
      Steven Brandenburg, who worked as a pharmacist with the Advocate Aurora Health hospital system has admitted he deliberately removed 57 vials of the Moderna vaccine from refrigeration and left them out overnight on Dec. 24 and again on Dec. 25. After leaving them out at room temperature overnight on Christmas Eve, Brandenburg returned the vials to their proper storage. But after pulling them out the second night they were discovered by a pharmacy technician.
      As a result of Brandenburg’s tampering, health care workers were forced to discard about 570 doses of the potentially life-saving medicine. Hospital officials said 57 individuals did receive injections of what may have been useless doses. Those patients have been notified and are not at any risk of adverse health effects, hospital officials said on Friday. pharmacist last week told investigators he knew “that people who received the vaccinations would think they had been vaccinated against the virus when in fact they were not,” officials said.

  16. Doc says:

    “Ohio researchers say they’ve identified two new Covid strains likely originating in the U.S.” https://www.cnbc.com/2021/01/13/ohio-researchers-say-theyve-identified-two-new-covid-strains-likely-originating-in-the-us.html
    “Global scientists double down on SARS-CoV-2 variants research at WHO-hosted forum” https://www.who.int/news/item/12-01-2021-global-scientists-double-down-on-sars-cov-2-variants-research-at-who-hosted-forum
    “Update on U.S. Withdrawal from the World Health Organization” https://www.state.gov/update-on-u-s-withdrawal-from-the-world-health-organization/

  17. Nightmare fuel says:

    “Covid vaccination efforts in the U.S. need to contend with Americans who don’t want to receive the shot, Dr. Scott Gottlieb told CNBC. https://www.cnbc.com/2021/01/19/covid-vaccine-dr-scott-gottlieb-estimates-only-120-million-americans-really-want-it.html
    “I think once we get to 100 million, maybe 120 million vaccines, the demand is going to get soft,” the former FDA chief said.
    “We can’t lose sight of that and just take for granted that everyone wants this vaccine,” he said.”

  18. Update says:

    “Newly identified COVID-19 strain in Los Angeles could be driving region’s virus surge, study suggests” https://www.cbsnews.com/news/covid-19-strain-in-los-angeles-could-be-driving-regions-virus-surge-study-suggests-2021-01-19/
    “Officials call for more vaccine doses as the US death toll passes 400,000” https://www.cnn.com/2021/01/20/health/us-coronavirus-wednesday/index.html
    “More than 16,000 vaccine doses potentially spoiled in Maine and Michigan by temperature problems” https://www.washingtonpost.com/nation/2021/01/20/moderna-vaccine-spoiled-maine-michigan/
    “NYC Reschedules 23,000 Vaccine Appointments Due to Shortage” https://www.bloomberg.com/news/articles/2021-01-20/nyc-reschedules-23-000-vaccine-appointments-due-to-shortage
    Published 24 mins ago
    “Outgoing Centers for Disease Control and Prevention (CDC) Director Robert Redfield defends CDC’s COVID-19 vaccine rollout, warns ‘worst is yet to come’ in pandemic” https://www.foxnews.com/health/redfield-cdc-covid-vaccine-pandemic

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