Less sugar…More muscle!

Researchers from Tokyo Metropolitan University have shown that skeletal muscle satellite cells, key players in muscle repair, proliferate better in low glucose environments. This is contrary to conventional wisdom that says mammalian cells fare better when there is more sugar to fuel their activities. Because ultra-low glucose environments do not allow other cell types to proliferate, the team could produce pure cultures of satellite cells, potentially a significant boost for biomedical research.

Healthy muscles are an important part of a healthy life. With the wear and tear of everyday use, our muscles continuously repair themselves to keep them in top condition. In recent years, scientists have begun to understand how muscle repair works at the cellular level. Skeletal muscle satellite cells have been found to be particularly important, a special type of stem cell that resides between the two layers of sheathing, the sarcolemma and basal lamina, that envelopes myofiber cells in individual muscle fibers. When myofiber cells get damaged, the satellite cells go into overdrive, multiplying and finally fusing with myofiber cells. This not only helps repair damage, but also maintains muscle mass. To understand how we lose muscles due to illness, inactivity, or age, getting to grips with the specific mechanisms involved is a key challenge for medical science.

Click through to the original article. Even the unanswered questions are interesting. A topic worth tracking.

Trump’s end-of-campaign money bomb was “unfair, unethical and inappropriate”

Donald Trump’s 2020 presidential campaign used pre-checked boxes and obscure design on fundraising emails to wring millions of dollars out of unwitting supporters, detonating a “money bomb”…The practice, pursued by the campaign and WinRed, a for-profit company, was detailed in an extensive report by the New York Times on Saturday. It is legal, but Ira Rheingold, executive director of the National Association of Consumer Advocates, told the paper it was “unfair, unethical and inappropriate”…

The “money bomb” did not bring victory, as Trump lost the electoral college by 306 votes to 232. He also lost the popular vote by more than 7 million ballots…

The Times reported that the practice was used for the Georgia Senate runoffs in January and continues to be used by the Republican party…It also detailed distressing experiences affecting Trump donors hit by surprise deductions and consequent trouble with banks and credit card companies.

I don’t know why the courts haven’t (yet) ruled this kind of activity as criminal fraud. Trump and his Republican bubbas had to refund over $64 million after the voting season ended. No one did any jail time.