Fascinating story – carrying technological roots forward over a century.
Fascinating story – carrying technological roots forward over a century.
❝ Babies made from two women and one man have been approved by the UK’s fertility regulator…The historic and controversial move is to prevent children being born with deadly genetic diseases.
Doctors in Newcastle – who developed the advanced form of IVF – are expected to be the first to offer the procedure and have already appealed for donor eggs.
The first such child could be born, at the earliest, by the end of 2017.
❝ Some families have lost multiple children to incurable mitochondrial diseases, which can leave people with insufficient energy to keep their heart beating.
The diseases are passed down from only the mother so a technique using a donor egg as well as the mother’s egg and father’s sperm has been developed.
The resulting child has a tiny amount of their DNA from the donor, but the procedure is legal and reviews say it is ethical and scientifically ready…
❝ Clinics can now apply to the HFEA for a licence to conduct three-person IVF…
The team at Newcastle-upon-Tyne Hospitals NHS Foundation Trust and Newcastle University is expected to be the first to be granted a licence…
❝ NHS England has agreed to fund the treatment costs of the first trial of three-person IVF for those women who meet the HFEA criteria, as long as they agree to long-term follow up of their children after they are born.
OK for the UK. Anyone think it will be legal anytime soon in OK? Har.
RTFA for details about the procedure. Yes, this can lead to a slippery slope of cures that panic True Believers and the whole brigade of anti-science whiners.
While opposition to scientific progress hasn’t especially grown since, say, the Victorian era, it boggles the mind how spooky, sanctimonius bible-thumping scares the crap out of purportedly modern politicians.
❝ Most everyone knows that the islands of the South Pacific are some of the most remote and unique places on Earth, but a new study reveals just how unique they really are.
…Researchers have found traces of a previously unknown extinct hominid species in the DNA of the Melanesians, a group living in an area northeast of Australia that encompasses Papua New Guinea and the surrounding islands.
❝ A computer analysis suggests that the unidentified ancestral hominid species found in Melanesian DNA is unlikely to be either Neanderthal or Denisovan, the two known predecessors of humankind to this point.
❝ Archaeologists have found many Neanderthal fossils in Europe and Asia, and although the only Denisovan DNA comes from a finger bone and a couple of teeth discovered in a Siberian cave, both species are well represented in the fossil record.
But now genetic modeling of the Melanesians has revealed a third, different human ancestor that may be an extinct, distinct cousin of the Neanderthals.
“We’re missing a population, or we’re misunderstanding something about the relationships,” said researcher Ryan Bohlender…“Human history is a lot more complicated than we thought it was.”
One of the confounding delights of scientific methods becoming more accurate, more capable of revealing features contributing to a much larger system – the analysis can become more complex and expand the search for knowledge at the same time.
Larry Don Patterson and William Lloyd Harbour
❝ An investigator “with a bit of free time” decided to send for testing DNA samples from a long-dormant cold case, which led authorities to arrest a pair of men linked to the 1973 shotgun slayings of two young girls, authorities said.
Police in Oklahoma and California arrested the two 65-year-old suspects Tuesday morning for the murders of Valerie Janice Lane, 12, and Doris Karen Derryberry, 13.
❝ The seventh grade classmates told their mothers they were going to a mall shopping near their homes about 40 miles north of Sacramento on Nov. 12, 1973. Witnesses saw them in their neighborhood that night, but neither girl returned home. Both suspects were living in Olivehurst at that time, investigators said.
Two boys were target shooting and found the girl’s bodies about 20 hours later, according to news accounts at the time. Investigators say the girls were driven to a wooded area and shot at close range.
Authorities then and now said a large-scale investigation was immediately launched and some 60 people interviewed over a three-year period before the case went cold for a lack of solid leads and was shelved in 1976.
❝ In March 2014, an investigator doing a routine look through cold cases decided to send semen samples found on Derryberry’s body and preserved for 43 years to the state Department of Justice forensics lab for analysis. Seven months later, state DOJ technicians reported that the DNA in the semen matched the genetic profiles of cousins Larry Don Patterson and William Lloyd Harbour, who each committed serious enough crimes since 1973 to have their DNA samples collected and placed in law enforcement computer systems.
❝ “Over time, anyone that’s been assigned to our investigations unit for any length of time looks into some of the unsolved cases that we have,” Yuba County Sheriff Steve Durfor said. “And this was one in particular that one of our investigators had a bit of free time and really looked very closely at this case and identified that we should send some things off and see what it might yield for us.”…
❝ Patterson was arrested Tuesday morning in Oklahoma. Harbour was arrested after a traffic stop two hours later near his home in Olivehurst, where the two victims also lived.
Both are now charged with murder. Overdue, for sure. But, the cases move towards completion because folks in the Yuba County Sheriff’s Department lived up to standards that should define all police departments. Coppers who really deserve medals.
Wrongfully imprisoned when he was 27 years old
❝ As he walked into the Virginia sun after spending 33 years in prison for crimes authorities now say he didn’t commit, the fact that his parents weren’t there to see him become a free man weighed heavily on Keith Allen Harward’s mind.
“That’s the worst part of this,” said Harward, who choked back tears as he spoke about his parents, who both died while he was wrongfully imprisoned. “I’ll never get that back.”
❝ Harward was released from the Nottoway Correctional Center on Friday after the Virginia Supreme Court agreed that DNA evidence proves he’s innocent of the 1982 killing of Jesse Perron and the rape of his wife in Newport News…
❝ The Innocence Project got involved in Harward’s case about two years ago and pushed for DNA tests, which failed to identify Harward’s genetic profile in sperm left at the crime scene. The DNA matched that of one of Harward’s former shipmate’s, Jerry L. Crotty, who died in an Ohio prison in June 2006, where he was serving a sentence for abduction…
❝ Harward initially faced the death penalty, but a loophole in the law caused his capital murder conviction to be overturned in 1985, said Olga Akselrod, another Innocence Project attorney.
“The fact that this case involved an innocent man who faced the death penalty should terrify everyone, not just in the state of Virginia but also in the 31 other states that still have the death penalty,” Akselrod said.
❝ Harward said he’s heading to his home state of North Carolina with family, who acknowledged that it will take him some time to get used to his new world.
“Keith is stepping out of a time capsule into a different world. We’re going to try to help him all we can,” said his brother, Charles Harward.
Harward said he’s looking forward to having some fried oysters as soon as he can. Beyond that, he’s not so sure. He just excited to be free to do whatever he wants.
“Go out and hug a tree, sit in a park. Whatever I want to do. Because I can.”
The state of Virginia almost executed a man, they imprisoned him for 33 years on bite mark evidence that’s hardly conclusive in any scientific forensics lab. After the rape victim didn’t identify him.
If it weren’t for modern technology like DNA testing – and the dedication of efforts like the Innocence Project – states like Virginia would continue to lock away individuals on mediocre evidence. And Keith Allen Harward would still be in prison.
Christopher Voigt talking about engineering biology
…The Broad Institute Foundry, a synthetic biology laboratory at MIT, has announced its new contract with DARPA. The lab will receive $32 million for engineering cells to find better treatments for disease, make new biofuels, or create fabrics woven with life.
“Living cells are the ultimate engineering substrate. They are the most difficult thing out there to be able to control,” says Christopher Voigt, professor of biomedical engineering…
“Imagine being able to engineer a living cell that can navigate the human body, identify disease, and correct that disease. That requires that the cell be able to sense where they are in the body, be able to detect it, and deliver a therapeutic. And that’s something that biology, we know it can do. But we don’t know how to harness that as part of a medicine.”
The Foundry is one of many labs working to manipulate the DNA of bacteria and other types of cells to make certain molecules—researchers have created cells that can make wood or seashells, for example. The work has mostly been limited to simple organic molecules, and progress has been slow since it takes a while for DNA to be put into cells and for those cells to mature.
With the DARPA contract, the Foundry will be able to join forces with other academics working on synthetic biology and computer science, as well as companies in various industries “including chemicals, pharmaceuticals, food, energy, agriculture, and biotechnology,” according to the press release…
The POPSCI article tries to crystal ball what the lab will come up with to keep DARPA happy. Military end-users are DARPA’s assigned market; so, a narrow view is easy. But, DARPA also has a history of supporting bona fide basic research that ended up with broad results – for example – like the Internet.
OTOH, I imagine the conjoined left-and-right Luddites who crap their knickers over anything involving DNA, genetic manipulation, pretty much anything that triggers superstition and anti-science fears – will spend the next few years cranking up their journalistic conspiracy machine – aiming it at MIT.
Everywhere you go, in everything you do, you are surrounded by an aura of microbes. They drift down from your hair when you scratch your head, they fly off your hand when you wave to your friend, they spew out of your mouth when you talk. Even when you sit around doing nothing, you’re sitting in your own, personal microbial bubble.
Made up of millions, billions, trillions of bacteria, yeast, cells, and cell parts, this bubble is actually more like a cloud — a cloud, new research suggests, that is unique to you. And as gross as it is to imagine everyone around you shedding microbial bits and pieces into the air, studying those clouds can be useful for people like doctors tracking down disease outbreaks and cops tracking down criminals.
The gut microbiome, often invoked in expensive probiotic-heavy diets, is probably the hottest microscopic community right now. It’s the collection of microbiota, living inside you, that helps you break down food, fight disease, and control your hunger.
But your outer body has its own microbiome, too. Your body is covered in skin, and that skin is like a vast savannah populated with millions of exotic critters. They feed on the oils seeping from your skin, dead cells, bits of organic matter, and each other. “In a single centimeter of skin, you can find thousands of bacteria,” says James Meadow, former University of Oregon researcher and co-author of a microbiome paper published…in the journal PeerJ.
Combined, the non-you cells in your body outnumber the you cells by about 10 to one. And if some sadistic scientist were to grind up and sequence all the DNA in every cell in and on your body, only about 2 percent of the genetic material would be human. The rest is microbes…
So how different could individuals’ microbial clouds really be? The two trials showed that, at least in these 11 people, microbial clouds varied significantly from person to person. They also found that different people shed microbes at different rates…
That knowledge will help shape microbiome cloud research in fields like contagious disease and forensics. In hospitals, nobody really knows how germs spread. Since leaving Oregon State University, Meadow has joined a biotech company in San Francisco that wants to use the understanding of microbial clouds to help hospitals prevent things like MRSA outbreaks.
Cops see other opportunities for the microbial cloud. Gilbert has been helping crime scene investigators use microbial residue to track down criminals. He says people pick up microbes from the soil, the air, the food they eat, and the water they wash and drink with. So an individual’s unique microbial signature could put them at the scene of a crime—or exonerate them if the microbes in their cloud match their alibi.
Any guess as to who gets the most funding, first?
The bond between humans and dogs can feel very strong, deep and profound. It may also be much older than we once thought.
A group of researchers discovered an ancient wolf bone and say its DNA suggests dogs diverged from wolves 27,000 to 40,000 years ago — not 11,000 to 16,000 years ago, as previous research has suggested. The researchers published their findings Thursday in the journal Current Biology.
In this latest study, researchers radiocarbon-dated a Taimyr wolf bone they found in Siberia and concluded it to be about 35,000 years old. Researchers point to the ancient wolf as possibly the most recent common relative of modern wolves and dogs.
That means two things could have happened about 40,000 years ago, with the simplest scenario being that dogs became domesticated.
“The only other explanation is that there was a major divergence between two wolf populations at that time, and one of these populations subsequently gave rise to all modern wolves,” study co-author Love Dalén of the Swedish Museum of Natural History said in a release.
Under that theory, the second wolf population would had to have gone extinct…
“The difference between the earlier genetic studies and ours is that we can calibrate the rate of evolutionary change in dog and wolf genomes directly, and we find that the first separation of dog ancestors must have been in the older range,” Skoglund told Reuters.
Another implication of this study: re-imagining how dogs became an important part of human society. As the BBC notes, a prevalent theory is that dogs became domestic creatures once humans settled into agricultural-based communities.
Humans could have also “caught wolf cubs and kept them as pets and this gradually led to these wild wolves being domesticated,” Dalen told BBC. “If this model is correct, then dogs were domesticated by hunter gatherers that led a fairly nomadic lifestyle.”
Being a longterm dog family, we’ve always felt that some extra smart dogs figured out we were a soft touch and moved in.
Would you find it frightening— perhaps even downright Orwellian — to know that a DNA swab that you sent to a company for recreational purposes would surface years later in the hands of police? What if it caused your child to end up in a police interrogation room as the primary suspect in a murder investigation?
In an extremely troubling case out of Idaho Falls, that’s exactly what happened.
Police investigating the 1996 murder of Angie Dodge targeted the wrong man as the suspect, after looking to Ancestry.com owned Sorensen Database labs for help. The labs look for familial matches between the murderers DNA and DNA submitted for genealogical testing after failing to find a match using traditional methods.
The cops chose to use a lab linked to a private collection of genetic genealogical data called the Sorenson Database (now owned by Ancestry.com), which claims it’s “the foremost collection of genetic genealogy data in the world.” The reason the Sorenson Database can make such an audacious claim is because it has obtained its more than 100,000 DNA samples and documented multi-generational family histories from “volunteers in more than 100 countries around the world.” Some of these volunteers were encouraged by the Mormon Church—well-known for its interest in genealogy—to provide their genetic material to the database. Sorenson promised volunteers their genetic data would only be used for “genealogical services, including the determination of family migration patterns and geographic origins” and would not be shared outside Sorenson….
Despite this promise, Sorenson shared its vast collection of data with the Idaho police. Without a warrant or court order, investigators asked the lab to run the crime scene DNA against Sorenson’s private genealogical DNA database. Sorenson found 41 potential familial matches, one of which matched on 34 out of 35 alleles—a very close match that would generally indicate a close familial relationship. The cops then asked, not only for the “protected” name associated with that profile, but also for all “all information including full names, date of births, date and other information pertaining to the original donor to the Sorenson Molecular Genealogy project.”
Vo Huu Nhan was in his vegetable boat in the floating markets of the Mekong Delta when his phone rang. The caller from the United States had stunning news — a DNA database had linked him with a Vietnam vet thought to be his father.
Nhan, 46, had known his father was an American soldier named Bob, but little else.
“I was crying,” Nhan recalled. “I had lost my father for 40 years, and now I finally had gotten together with him.”
The journey toward their reconciliation has not been easy. News of the DNA match set in motion a chain of events involving two families 8,700 miles apart that is still unfolding and has been complicated by the illness of the veteran, Robert Thedford Jr., a retired deputy sheriff in Texas.
When the last American military personnel fled Saigon on April 29 and 30, 1975, they left behind a country scarred by war, a people uncertain about their future and thousands of their own children.
These children — some half-black, some half-white — came from liaisons with bar girls, “hooch” maids, laundry workers and the laborers who filled sandbags to protect American bases.
They are approaching middle age with stories as complicated as the two countries that gave them life. Growing up with the face of the enemy, they were spat on, ridiculed, beaten…They were called “bui doi,” which means “the dust of life.”
Forty years later, hundreds remain in Vietnam, too poor or without proof to qualify for the program created by the Amerasian Homecoming Act of 1987 that resettles the children of American soldiers in the United States.
Now, an Amerasian group has launched a last-chance effort to reunite fathers and children with a new DNA database on a family heritage website. Those left behind have scant information about their GI dads. DNA matches are their only hope.
RTFA for detail, anecdotes – even some good news. I’m not surprised the grunt side of the war is doing something to sort out what our nation “accomplished” in Southeast Asia.
I don’t expect today’s crew in Congress to do a damned thing?