Is Alzheimers drug Aducanumab a breakthrough or a boondoggle?

Patients and their families may see hope in the news that the Food and Drug Administration has approved a drug to slow the pace of Alzheimer’s disease. Aducanumab is the first medicine authorized to treat what might be an underlying cause of the disease: amyloid beta clumps that accumulate in the brain. Yet the evidence from clinical trials that this drug reduces Alzheimer’s is incomplete; it may be only minimally effective, if it works at all. The FDA’s own expert panel strongly objected to the drug’s approval.

All of which makes the FDA’s announcement both perplexing and wrong. It threatens to mislead millions of Alzheimer’s patients. At the same time, because Biogen plans to price the drug at $56,000 a year for the average patient, it also stands to cost Medicare and other insurers a bundle. This underlines the need for two kinds of reform. First, the FDA needs to rethink its processes for approving drugs. Second, the rules controlling how Medicare chooses and pays for medicines need a thorough overhaul.

The FDA has failed to fully explain why it overruled the almost unanimous advice of its advisory panel on aducanumab. The agency didn’t deny that the clinical-trial evidence was poor. It simply ignored that problem and used different reasoning to grant the drug “accelerated approval.”…In fact, it’s a more limited endorsement than ordinary approval, indicating that the drug has not proven a “real effect on how a patient survives, feels or functions,” in the FDA’s words, but nevertheless acts on an underlying disease process in a way that might predict such a benefit…

Despite that, Biogen will sell aducanumab — under the brand name Aduhelm — at an exorbitant cost…The nonprofit Institute for Clinical and Economic Review has said that even if the drug works as well as Biogen suggests it can, it would be cost-effective at a price of $2,600 to $8,300 a year…

But, hey…Congress apparently thinks Biogen should get every penny they can squeeze from us, our tax dollars and anything else they lay their greedy hands on.

J.P.Morgan puts Republicans who support Trump’s election lies into the donations deep freezer

JPMorgan Chase & Co will resume making political donations to United States lawmakers but will not give to Republican members of Congress who voted to overturn President Joe Biden’s election victory, according to an internal memo on Friday seen by Reuters news agency.

The bank was among many corporations that paused political giving following the deadly January 6 Capitol riots when supporters of former president Donald Trump tried to stop Congress from certifying the election…

The pause will last through the 2021-2022 election cycle, which includes November’s midterm elections, after which JPMorgan will review whether to resume contributions to the lawmakers concerned on an individual basis.

Wouldn’t it be special if Trumpo scumbags actually earned their subsidies by doing something useful…instead of the usual scam, relying on payoffs from business donors who mostly fear what stupidity these pimps will come up with, next?

El Trumpo continues to pardon crooks and his other peers

“If you once forfeit the confidence of your fellow citizens, you can never regain their respect and esteem. It is true that you may fool all of the people some of the time; you can even fool some of the people all of the time; but you can’t fool all of the people all of the time.”

Abraham Lincoln, September 8, 1854.

In his first television interview since being pardoned by President Trump, longtime Republican consultant Roger Stone…praised the president as the greatest since Abraham Lincoln.

Yes, the Republican Party, nowadays, is controlled by crooks, frauds and pimps who ignore history, reality and truth…all of the time.

Fake president is scared of genuine civil servants


Yuri Gripas/Reuters

“My 42-year career began during the Carter administration and involved service to seven presidents: four Republicans and three Democrats. Most recently, I had the privilege of leading the dedicated professionals of the National Counterterrorism Center; over four decades, I worked throughout the intelligence community, on the National Security Council and overseas…”
***********
U.S. Senators Marco Rubio and Mark Warner, heads of the Senate intelligence committee, voiced their support for whistleblowers on Friday after a former counterterrorism official fired by the Trump administration filed a complaint.

The senators’ joint statement reflected concern from both Senate Democrats and Republicans over the politicization of U.S. spy agencies under President Donald Trump with the appointments of loyalists to leadership positions.

A congressional source said their statement was prompted by a complaint about political interference in the intelligence process made by Russell Travers, a veteran intelligence officer ousted recently as acting chief of the National Counterterrorism Center…

Even suits like Rubio and Warner realize the value of non-partisan, experienced, civil servants vs the obedient sock puppets the Fake President loves putting into important jobs. They’re eager to kiss his ignorant butt…even though one of their prime roles is to take the fall for trying to implement the crap proto-fascist ideology he dotes on.

Palestinians vow to fight Trump’s plan to expand Israeli colonialism


Arwa Ibrahim/Al Jazeera

Tens of thousands of worshippers have descended on the Al-Aqsa Mosque compound for the first Friday prayers after US President Donald Trump announced his Middle East plan to resolve the decades-old Palestinian-Israeli conflict…

Under Trump’s plan, the eighth-century site, regarded by Muslims as the third holiest site in Islam and important for all three Abrahamic faiths, would be under Israeli control

In 1947, the United Nations drew up a plan to divide Palestine between Jews and Palestinians, leading to the creation of Israel. Since then, the Al-Aqsa compound has been under UN administration.

Palestinians decry the increasing Israeli encroachment over the site, which intensified after the 1967 war, which resulted in an Israeli occupation of East Jerusalem, where the Old City and the Mosque are located.

Trump’s 181-page document says Jerusalem’s holy sites “should remain open and available for peaceful worshippers and tourists of all faiths”…


The two smirking pimps who decide who is “peaceful”